Abstract: Objective To analyze the clinical characteristics, treatment, and prognosis of post-infectious bronchiolitis obliterans (PIBO) in children. Methods Clinical data from 35 children diagnosed with PIBO were retrospectively analyzed from April 2010 to June 2015. The children were divided into different groups according to the length of glucocorticoid use, and the prognosis were compared. Results Thirty-five children all presented cough and wheezing. There were 12 cases in the group of less than one year of glucocorticoid treatment, 8 cases in the group of 1-2 years of glucocorticoid treatment, and 6 cases in the group of great than or equal to 2 years of glucocorticoid treatment. There was no significant difference in the prognosis among the groups (P > 0.05). Conclusions The overall prognosis is poor in children with PIBO, even if the symptoms are improved. Glucocorticoid is helpful to remiss the symptoms of cough and wheezing, but prolonged use have no significant effect on the prognosis.